Chronic Myeloid Leukemia (CML)
I. Introduction & Epidemiology II. Pathogenesis (Figure 1) CML is driven by a single genetic event — the formation of the BCR::ABL1 fusion gene. Understanding this mechanism explains the disease biology, clinical features, and treatment rationale. A. The Philadelphia Chromosome B. Translocation Variants The classic t(9;22) is present in >90% of cases, but variant forms…